Credit: Getty Images. Chronic itching is a common side effect of opioids—a problem for some people who need the drugs for pain relief and for others fighting addiction.
Itching after epidural and spinal opiates.
A new study with mice finds a drug delivers itch relief fro targeting particular opioid receptors on neurons in the spinal cord. Nalfurafine hydrochloride brand name Remitch is approved in Japan to alleviate itching in dialysis patients with How to stop itching from opiates kidney disease and Any cougars virgins or bbws patients with severe liver disease.
While other opioid receptors on the same neurons can ramp up itching, this study shows that activating the kappa receptor significantly dials it down.
Chen and colleagues studied mice treated with a substance to make them feel itchy. Others had been genetically engineered to develop chronic itching.
When the drug was injected directly into the spinal cords of the animals, their scratching was markedly reduced. About half of the neurons in the spinal cord that transmit How to stop itching from opiates signals were found to have kappa opioid receptors, and when those receptors are activated, they inhibit GRPR.
It may not be practical to administer spinal cord injections of drugs to patients with chronic itch—whatever the cause—but now that a way to alleviate such itching has been identified, researchers can try to activate the same receptor in other ways.
Or, Chen says, they may target some of the downstream molecules that are activated when the kappa receptor is targeted. His team is now working to learn whether those strategies will work in mice, with the hope that the same molecules eventually may become therapeutic go in people with chronic itch.
Source: Washington University in St. Search for:. Science Health Culture Environment.
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